Article

Antigen-experienced CXCR5<sup>-</sup>CD19<sup>low</sup>B cells are plasmablast precursors expanded in SLE

2021-05-27

Abstract excerpt

B cells play a critical role in the pathogenesis of systemic lupus erythematosus (SLE). We analysed two independent cohorts of healthy donors and SLE patients using a combined approach of flow and mass cytometry. We have found that IgD - CD27 + switched and atypical IgD - CD27 - memory B cells, which are increased in SLE, represent heterogeneous populations composed each of three different subsets, such as CXCR5 +...

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Literature Corpus work: 16727cfd-f45b-5173-ad56-fe5529ac4b04
DOI: 10.1101/2021.05.25.21257784

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