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Article

Plasma cells are not restricted to the CD27+ phenotype: characterization of CD27-CD43+ antibody-secreting cells.

Frontiers in immunology - 1 Jan 2023

Covens Kris, Verbinnen Bert, de Jong Britt G, Moens Leen, Wuyts Greet, Verheyen Geert, Nys Kris, Cremer Jonathan, Smulders Stijn, Schrijvers Rik, Weinhäusel Andreas, Vermeire Séverine, Verschueren Patrick, Langhe Ellen De, van Dongen Jacques J M, van Zelm Menno C, Bossuyt Xavier

Abstract excerpt

Circulating antibody-secreting cells are present in the peripheral blood of healthy individuals reflecting the continued activity of the humoral immune system. Antibody-secreting cells typically express CD27. Here we describe and characterize a small population of antibody-secreting class switched CD19+CD43+ B cells that lack expression of CD27 in the peripheral blood of healthy subjects. In this study, we...

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Identifiers

PMID: 37492569
DOI: 10.3389/fimmu.2023.1165936
PMCID: PMC10364057

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