Altered Phenotype and Enhanced Antibody-Producing Ability of Peripheral B Cells in Mice with Cd19-Driven Cre Expression.

doi:10.3390/cells11040700

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Article

Altered Phenotype and Enhanced Antibody-Producing Ability of Peripheral B Cells in Mice with Cd19-Driven Cre Expression.

Cells - 16 Feb 2022

Zhao Ying, Zhao Sai, Qin Xiao-Yuan, He Ting-Ting, Hu Miao-Miao, Gong Zheng, Wang Hong-Min, Gong Fang-Yuan, Gao Xiao-Ming, Wang Jun

Abstract excerpt

Given the importance of B lymphocytes in inflammation and immune defense against pathogens, mice transgenic for Cre under the control of Cd19 promoter (Cd19Cre/+ mice) have been widely used to specifically investigate the role of loxP-flanked genes in B cell development/function. However, impacts of expression/insertion of the Cre transgene on the phenotype and function of B cells have not been carefully studied....

Topics

Animals
Antibodies
Antigens, CD19
B-Lymphocytes
Integrases
Mice
Mice, Inbred C57BL
Phenotype

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Identifiers

PMID: 35203346
DOI: 10.3390/cells11040700
PMCID: PMC8870415

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