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Polymorphism of organic cation transporter 2 improves glucose-lowering effect of metformin via influencing its pharmacokinetics in Chinese type 2 diabetic patients.

Molecular diagnosis & therapy - 1 Feb 2015

Hou Wolin, Zhang Dandan, Lu Wei, Zheng Taishan, Wan Lili, Li Qing, Bao Yuqian, Liu Fang, Jia Weiping

Abstract excerpt

BACKGROUND AND OBJECTIVES: This study aimed to investigate how the organic cation transporter 2 nucleotide polymorphism at site 808 (G → T) affects metformin pharmacokinetics and its long-term anti-diabetic effect. METHODS: A total of 220 newly diagnosed type 2 diabetes patients taking oral metformin were recruited, genotyped and then divided into three groups by SLC22A2 genotypes (G/G, G/T, T/T). Nine patients...

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PMID: 25573751
DOI: 10.1007/s40291-014-0126-z

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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