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Article

Effects of the genetic variants of organic cation transporters 1 and 3 on the pharmacokinetics of metformin in Jordanians.

Drug metabolism and personalized therapy - 26 Sept 2017

Hakooz Nancy, Jarrar Yazun Bashir, Zihlif Malik, Imraish Amer, Hamed Saja, Arafat Tawfiq

Abstract excerpt

BACKGROUND: Human response to the antidiabetic metformin is influenced by some factors, such as genetic variants in the SLC22A genes. This study aimed to determine the frequency of main SLC22A1 and SLC22A3 genetic variants and their influence on metformin pharmacokinetics among healthy unrelated Arab Jordanians. PATIENTS AND METHODS: The SLC22A1 and SLC22A3 genes were genotyped by DNA sequencing of exons 1, 3, 7,...

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Identifiers

PMID: 28862982
DOI: 10.1515/dmpt-2017-0019

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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