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Article

Genetic variants of the organic cation transporter 2 influence the disposition of metformin.

Clinical pharmacology and therapeutics - 1 Nov 2008

Song I S, Shin H J, Shim E J, Jung I S, Kim W Y, Shon J H, Shin J G

Abstract excerpt

Genetic variants of the organic cation transporter 2 (protein, OCT2; gene, SLC22A2) were evaluated for their contribution to the variations in the pharmacokinetics of metformin, especially to its renal elimination. Genetic variants of SLC22A2 (c.596C>T, c.602C>T, and c.808G>T) showed significant...

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PMID: 18401339
DOI: 10.1038/clpt.2008.61

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-18401339-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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