SLC47A1 gene rs2289669 G>A variants enhance the glucose-lowering effect of metformin via delaying its excretion in Chinese type 2 diabetes patients.

doi:10.1016/j.diabres.2015.05.003

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

SLC47A1 gene rs2289669 G>A variants enhance the glucose-lowering effect of metformin via delaying its excretion in Chinese type 2 diabetes patients.

Diabetes research and clinical practice - 1 Jul 2015

He Rui, Zhang Dandan, Lu Wei, Zheng Taishan, Wan Lili, Liu Fang, Jia Weiping

Abstract excerpt

AIMS: The SLC47A1 gene encodes the multi-drug and toxic excretion-1(MATE1) protein, which plays a key role in the transport and excretion of metformin. This study is to clarify the influence of variants in SLC47A1 (rs2289669 G→A) on metformin pharmacokinetics and the long-term glucose-lowering effect of metformin. METHODS: A total of 220 newly diagnosed type 2 diabetes patients were recruited, genotyped and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Administration, Oral

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Aged

Share to Asian People

Share to Diabetes Mellitus, Type 2

Share to Hypoglycemic Agents

Share to Metformin

Share to Organic Cation Transport Proteins

Share to Polymorphism, Single Nucleotide

Source

Open in PubMed

Identifiers

PMID: 26004431
DOI: 10.1016/j.diabres.2015.05.003

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

SLC47A1 gene rs2289669 G>A variants enhance the glucose-lowering effect of metformin via delaying its excretion in Chinese type 2 diabetes patients.PMID 26004431Read ↗

Association of SLC22A1, SLC22A2, SLC47A1, and SLC47A2 Polymorphisms with Metformin Efficacy in Type 2 Diabetic PatientsSemantic proximity Read ↗

The influence of metformin transporter gene SLC22A1 and SLC47A1 variants on steady-state pharmacokinetics and glycemic response.Semantic proximity Read ↗

Polymorphism of organic cation transporter 2 improves glucose-lowering effect of metformin via influencing its pharmacokinetics in Chinese type 2 diabetic patients.Semantic proximity Read ↗

The Impacts of<i>SLC22A1</i>rs594709 and<i>SLC47A1</i>rs2289669 Polymorphisms on Metformin Therapeutic Efficacy in Chinese Type 2 Diabetes PatientsSemantic proximity Read ↗

Influence of Solute Carrier Family 22 Member 1 (SLC22A1) Gene Polymorphism on Metformin Pharmacokinetics and HbA1c Levels: A Systematic Review.Semantic proximity Read ↗

Altered Glycemic Control Associated With Polymorphisms in the SLC22A1 (OCT1) Gene in a Mexican Population With Type 2 Diabetes Mellitus Treated With Metformin: A Cohort StudySemantic proximity Read ↗

Pharmacogenomic association between a variant in SLC47A1 gene and therapeutic response to metformin in type 2 diabetes.Semantic proximity Read ↗

Genetic variation in the multidrug and toxin extrusion 1 transporter protein influences the glucose-lowering effect of metformin in patients with diabetes: a preliminary study.Semantic proximity Read ↗

The effect of novel promoter variants in MATE1 and MATE2 on the pharmacokinetics and pharmacodynamics of metformin.Semantic proximity Read ↗

A gene-gene interaction between polymorphisms in the OCT2 and MATE1 genes influences the renal clearance of metformin.Semantic proximity Read ↗

Solute carrier family 47 member 1 gene polymorphism detection improves the therapeutic effect of diabetes.Semantic proximity Read ↗

Differential increments of basal glucagon-like-1 peptide concentration among SLC47A1 rs2289669 genotypes were associated with inter-individual variability in glycaemic response to metformin in Chinese people with newly diagnosed Type 2 diabetes.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.