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Article

Clinical relevance of single nucleotide polymorphisms within the entire NLRP3 gene in patients with major blunt trauma.

Critical care (London, England) - 1 Jan 2011

Zhang An-Qiang, Zeng Ling, Gu Wei, Zhang Lian-Yang, Zhou Jian, Jiang Dong-po, Du Ding-Yuan, Hu Ping, Yang Ce, Yan Jun, Wang Hai-Yan, Jiang Jian-Xin

Abstract excerpt

INTRODUCTION: The nucleotide-binding oligomerization domain-like receptor (NLR) family has been recognized as comprising intracellular pattern recognition receptors in which NLRP3 (NLR family, pyrin domain containing 3) plays an important role in the initiation of host immune inflammatory responses. The genetic variants have been recognized to be critical determinants of interindividual differences in both...

Topics

Adult
Carrier Proteins
Female
Gene Frequency
Genotype
Haplotypes
Humans
Interleukin-1beta
Male
Multiple Organ Failure
NLR Family, Pyrin Domain-Containing 3 Protein

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Polymorphism, Single Nucleotide

Sepsis

Wounds, Nonpenetrating

Source

Open in PubMed Open full text

Identifiers

PMID: 22112657
DOI: 10.1186/cc10564
PMCID: PMC3388683

Genes

NLRP3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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