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Identification of haplotype tag SNPs within the entire TLR2 gene and their clinical relevance in patients with major trauma.

Shock (Augusta, Ga.) - 1 Jan 2011

Chen Ke-Hong, Gu Wei, Zeng Ling, Jiang Dong-Po, Zhang Lian-Yang, Zhou Jian, Du Ding-Yuan, Hu Ping, Liu Qing, Huang Su-Na, Jiang Jian-Xin

Abstract excerpt

Toll-like receptor 2 (TLR2) signaling plays a critical role in orchestrating the innate immune response and the development of sepsis and subsequent organ dysfunction after trauma. The objectives of this prospective study were to identify haplotype tag single-nucleotide polymorphisms (htSNPs) within the entire TLR2 gene and to investigate their clinical relevance in patients with major trauma. A total of 410...

Topics

Asian People
Genotype
Haplotypes
Humans
Interleukin-10
Interleukin-8
Multiple Organ Failure
Polymorphism, Restriction Fragment Length
Polymorphism, Single Nucleotide
Prospective Studies

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Sepsis

Toll-Like Receptor 2

Tumor Necrosis Factor-alpha

Wounds and Injuries

Source

Identifiers

PMID: 20577149
DOI: 10.1097/SHK.0b013e3181eb45b3

Genes

TLR2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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