Article
Clinical relevance of single nucleotide polymorphisms of the high mobility group box 1 protein gene in patients with major trauma in southwest China.
Surgery - 1 Mar 2012
Zeng Ling, Zhang An-Qiang, Gu Wei, Chen Ke-Hong, Jiang Dong-Po, Zhang Lian-Yang, Du Ding-Yuan, Hu Ping, Huang Su-Na, Wang Hai-Yan, Jiang Jian-Xin
Abstract excerpt
BACKGROUND: High-mobility group box protein 1 (HMGB1) is a pivotal late mediator involved in the development of sepsis and multiple organ dysfunction syndrome (MODS) in critically ill patients. While several single nucleotide polymorphisms (SNPs) have been demonstrated to be critical determinants for outcome of critically ill patients, little is known about the clinical relevance of SNPs of the HMGB1 gene up to...
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