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Article

Genome-wide association analysis of plasma B-type natriuretic peptide in blacks: the Jackson Heart Study.

Circulation. Cardiovascular genetics - 1 Feb 2015

Musani Solomon K, Fox Ervin R, Kraja Aldi, Bidulescu Aurelian, Lieb Wolfgang, Lin Honghuang, Beecham Ashley, Chen Ming-Huei, Felix Janine F, Fox Caroline S, Kao W H Linda, Kardia Sharon L R, Liu Ching-Ti, Nalls Mike A, Rundek Tatjana, Sacco Ralph L, Smith Jennifer, Sun Yan V, Wilson Gregory, Zhang Zhaogong, Mosley Thomas H, Taylor Herman A, Vasan Ramachandran S

Abstract excerpt

BACKGROUND: Numerous experimental studies suggest that B-type natriuretic peptide (BNP) is cardioprotective; however, in clinical studies, higher plasma BNP concentrations have been associated with incident cardiovascular disease and higher left ventricular mass. Genetic association studies may allow us to determine the true causal directions without confounding by compensatory mechanisms. METHODS AND RESULTS: We...

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Identifiers

PMID: 25561047
DOI: 10.1161/CIRCGENETICS.114.000900
PMCID: PMC4426827

Genes

KLKB1
NPPB

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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