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Article

Genetic association analysis of the cardiovascular biomarker: N-terminal fragment of pro-B-type natriuretic peptide (NT-proBNP).

PloS one - 1 Jan 2021

Yang Yuan, Zmuda Joseph M, Wojczynski Mary K, Thyagarajan Bharat, Christensen Kaare, Cvejkus Ryan K, Kuipers Allison L

Abstract excerpt

BACKGROUND: NT-proBNP is a biomarker of cardiovascular disease (CVD). Little is known about the heritability and genetic variants associated with NT-proBNP. Therefore, we estimated the heritability of and examined genetic associations of SNPs in the BNP gene region with circulating NT-proBNP and prevalent CVD in 4,331 participants from the Long Life Family Study (LLFS). METHODS AND RESULTS: Genotypes of 10 SNPs...

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Identifiers

PMID: 33720941
DOI: 10.1371/journal.pone.0248726
PMCID: PMC7959346

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