An NPPB Promoter Polymorphism Associated With Elevated N-Terminal pro-B-Type Natriuretic Peptide and Lower Blood Pressure, Hypertension, and Mortality.

doi:10.1161/JAHA.116.005257

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Article

An NPPB Promoter Polymorphism Associated With Elevated N-Terminal pro-B-Type Natriuretic Peptide and Lower Blood Pressure, Hypertension, and Mortality.

Journal of the American Heart Association - 24 Mar 2017

Seidelmann Sara B, Vardeny Orly, Claggett Brian, Yu Bing, Shah Amil M, Ballantyne Christie M, Selvin Elizabeth, MacRae Calum A, Boerwinkle Eric, Solomon Scott D

Abstract excerpt

BACKGROUND: Elevated B-type natriuretic peptide (BNP) levels are associated with heart failure and increased mortality in the general population. We investigated rs198389, a functional variant in the promoter region of the BNP gene (NPPB), in patients from the Atherosclerosis Risk in Communities Study to investigate associations with N-terminal pro-BNP (NT-proBNP) levels and outcomes. METHODS AND RESULTS: A total...

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PMID: 28341776
DOI: 10.1161/JAHA.116.005257
PMCID: PMC5533018

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NPPB

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