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Article

Genome-Wide Association Approach Identified Novel Genetic Predictors of Heart Rate Response to β-Blockers.

Journal of the American Heart Association - 24 Feb 2018

Shahin Mohamed H, Conrado Daniela J, Gonzalez Daniel, Gong Yan, Lobmeyer Maximilian T, Beitelshees Amber L, Boerwinkle Eric, Gums John G, Chapman Arlene, Turner Stephen T, Cooper-DeHoff Rhonda M, Johnson Julie A

Abstract excerpt

BACKGROUND: For many indications, the negative chronotropic effect of β-blockers is important to their efficacy, yet the heart rate (HR) response to β-blockers varies. Herein, we sought to use a genome-wide association approach to identify novel single nucleotide polymorphisms (SNPs) associated with HR response to β-blockers. METHODS AND RESULTS: We first performed 4 genome-wide association analyses for HR...

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Identifiers

PMID: 29478026
DOI: 10.1161/JAHA.117.006463
PMCID: PMC5866313

Genes

SNX9

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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