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Article

Genetic Architecture of N-Terminal Pro-B-Type Natriuretic Peptide in a Multiancestry Study Population.

Circulation. Genomic and precision medicine - 1 Feb 2026

Shetty Naman S, Pampana Akhil, Gaonkar Mokshad, Nayak Amrita, Bal Harshvir S, Patel Nirav, Vekariya Nehal, Smith J Gustav, Morrison Alanna C, Yu Bing, Psaty Bruce M, Boerwinkle Eric, Floyd James S, Rotter Jerome I, Taylor Kent D, Lange Leslie A, Irvin Marguerite R, Cushman Mary, Rich Stephen S, Vasan Ramachandran S, Wang Thomas J, Guo Xiuqing, Li Peng, Arora Garima, Arora Pankaj

Abstract excerpt

BACKGROUND: NPs (natriuretic peptides) are bioactive hormones crucial for regulating blood pressure, glucose homeostasis, and lipid metabolism. Despite the high heritability of circulating NP levels, the genetic determinants of NP regulation, particularly across ancestries and sexes, remain poorly understood. The objective of the current study was to identify genetic variants associated with NT-proBNP (N-terminal...

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PMID: 41603044
DOI: 10.1161/CIRCGEN.124.005130
PMCID: PMC13321388

Genes

BAG3
SLC39A8

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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