Article
Genome-wide meta-analyses of plasma renin activity and concentration reveal association with the kininogen 1 and prekallikrein genes.
Circulation. Cardiovascular genetics - 1 Feb 2015
Lieb Wolfgang, Chen Ming-Huei, Teumer Alexander, de Boer Rudolf A, Lin Honghuang, Fox Ervin R, Musani Solomon K, Wilson James G, Wang Thomas J, Völzke Henry, Petersen Ann-Kristin, Meisinger Christine, Nauck Matthias, Schlesinger Sabrina, Li Yong, Menard Jöel, Hercberg Serge, Wichmann H-Erich, Völker Uwe, Rawal Rajesh, Bidlingmaier Martin, Hannemann Anke, Dörr Marcus, Rettig Rainer, van Gilst Wiek H, van Veldhuisen Dirk J, Bakker Stephan J L, Navis Gerjan, Wallaschofski Henri, Meneton Pierre, van der Harst Pim, Reincke Martin, Vasan Ramachandran S
Abstract excerpt
BACKGROUND: The renin-angiotensin-aldosterone system (RAAS) is critical for regulation of blood pressure and fluid balance and influences cardiovascular remodeling. Dysregulation of the RAAS contributes to cardiovascular and renal morbidity. The genetic architecture of circulating RAAS components is incompletely understood. METHODS AND RESULTS: We meta-analyzed genome-wide association data for plasma renin...
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