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Article

Association of Exome Sequences With Cardiovascular Traits Among Blacks in the Jackson Heart Study.

Circulation. Cardiovascular genetics - 1 Aug 2016

Peloso Gina M, Lange Leslie A, Varga Tibor V, Nickerson Deborah A, Smith Joshua D, Griswold Michael E, Musani Solomon, Polfus Linda M, Mei Hao, Gabriel Stacey, Quarells Rakale Collins, Altshuler David, Boerwinkle Eric, Daly Mark J, Neale Benjamin, Correa Adolfo, Reiner Alex P, Wilson James G, Kathiresan Sekar

Abstract excerpt

BACKGROUND: The correlation of null alleles with human phenotypes can provide insight into gene function in humans. In individuals of African ancestry, we set out to identify null and damaging missense variants, and test these variants for association with a range of cardiovascular phenotypes. METHODS AND RESULTS: We performed whole-exome sequencing in 3223 black individuals from the Jackson Heart Study and found...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 27422940
DOI: 10.1161/CIRCGENETICS.116.001410
PMCID: PMC4988917

Genes

PCSK9
HBQ1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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