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Article

Increased arterial blood pressure and vascular remodeling in mice lacking salt-inducible kinase 1 (SIK1).

Circulation research - 13 Feb 2015

Bertorello Alejandro M, Pires Nuno, Igreja Bruno, Pinho Maria João, Vorkapic Emina, Wågsäter Dick, Wikström Johannes, Behrendt Margareta, Hamsten Anders, Eriksson Per, Soares-da-Silva Patricio, Brion Laura

Abstract excerpt

RATIONALE: In human genetic studies a single nucleotide polymorphism within the salt-inducible kinase 1 (SIK1) gene was associated with hypertension. Lower SIK1 activity in vascular smooth muscle cells (VSMCs) leads to decreased sodium-potassium ATPase activity, which associates with increased vascular tone. Also, SIK1 participates in a negative feedback mechanism on the transforming growth factor-β1 signaling...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Endothelin-1

Share to Myocytes, Smooth Muscle

Share to Sodium Chloride, Dietary

Share to Sympathetic Nervous System

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Source

Identifiers

PMID: 25556206
DOI: 10.1161/CIRCRESAHA.116.304529

Genes

SIK1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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