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Article

Essential Role of Smooth Muscle STIM1 in Hypertension and Cardiovascular Dysfunction.

Arteriosclerosis, thrombosis, and vascular biology - 1 Sept 2016

Kassan Modar, Ait-Aissa Karima, Radwan Eman, Mali Vishal, Haddox Samuel, Gabani Mohanad, Zhang Wei, Belmadani Souad, Irani Kaikobad, Trebak Mohamed, Matrougui Khalid

Abstract excerpt

OBJECTIVES: Chronic hypertension is the most critical risk factor for cardiovascular disease, heart failure, and stroke. APPROACH AND RESULTS: Here we show that wild-type mice infused with angiotensin II develop hypertension, cardiac hypertrophy, perivascular fibrosis, and endothelial dysfunction with enhanced stromal interaction molecule 1 (STIM1) expression in heart and vessels. All these pathologies were...

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Identifiers

PMID: 27470514
DOI: 10.1161/ATVBAHA.116.307869
PMCID: PMC5061131

Genes

STIM1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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