Salt-inducible kinase 1 influences Na(+),K(+)-ATPase activity in vascular smooth muscle cells and associates with variations in blood pressure.

doi:10.1097/HJH.0b013e32834d3d55

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Article

Salt-inducible kinase 1 influences Na(+),K(+)-ATPase activity in vascular smooth muscle cells and associates with variations in blood pressure.

Journal of hypertension - 1 Dec 2011

Popov Sergej, Silveira Angela, Wågsäter Dick, Takemori Hiroshi, Oguro Ryousuke, Matsumoto Sachiko, Sugimoto Ken, Kamide Kei, Hirose Takuo, Satoh Michihiro, Metoki Hirohito, Kikuya Masahiro, Ohkubo Takayoshi, Katsuya Tomohiro, Rakugi Hiromi, Imai Yutaka, Sanchez Fabio, Leosdottir Margret, Syvänen Ann-Christine, Hamsten Anders, Melander Olle, Bertorello Alejandro M

Abstract excerpt

OBJECTIVES: Essential hypertension is a complex condition whose cause involves the interaction of multiple genetic and environmental factors such as salt intake. Salt-inducible kinase 1 (SIK1) is a sucrose-nonfermenting-like kinase isoform that belongs to the AMPK (5' adenosine monophosphate-activated protein kinase) family. SIK1 activity is increased by high salt intake and plays an essential role in regulating...

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Identifiers

PMID: 22045124
DOI: 10.1097/HJH.0b013e32834d3d55

Genes

SIK1
DBP

Provenance

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