Article
Histone demethylase LSD1 deficiency during high-salt diet is associated with enhanced vascular contraction, altered NO-cGMP relaxation pathway, and hypertension.
American journal of physiology. Heart and circulatory physiology - 1 Nov 2011
Pojoga Luminita H, Williams Jonathan S, Yao Tham M, Kumar Abhinav, Raffetto Joseph D, do Nascimento Graciliano R A, Reslan Ossama M, Adler Gail K, Williams Gordon H, Shi Yujiang, Khalil Raouf A
Abstract excerpt
Histone methylation, a determinant of chromatin structure and gene transcription, was thought to be irreversible, but recent evidence suggests that lysine-specific demethylase-1 (LSD1, Kdm1a) induces demethylation of histone H3 lysine 4 (H3K4) or H3K9 and thereby alters gene transcription. We previously demonstrated a human LSD1 phenotype associated with salt-sensitive hypertension. To test the hypothesis that...
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