Article

Enhanced diastolic dysfunction but preserved systolic function after acute pressure overload in the absence of smoothelin-like 1 protein

2020-10-29

Abstract excerpt

<h4>Aims</h4> Smoothelin-like 1 (SMTNL1), a protein kinase A/G target protein, modulates the activity and expression of myosin light chain phosphatase and thus plays an important role in regulating vasoconstriction. Increased myogenic reactivity of resistance arterioles is associated with SMTNL1 silencing, and elevated baseline vascular tone is increasingly recognized as a risk factor for development of hypertens...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 9c4572ff-46ee-5eab-b0d7-22181a697215
DOI: 10.1101/2020.10.28.360065

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Enhanced diastolic dysfunction but preserved systolic function after acute pressure overload in the absence of smoothelin-like 1 proteinDOI 10.1101/2020.10.28.360065Read

Deletion of the protein kinase A/protein kinase G target SMTNL1 promotes an exercise-adapted phenotype in vascular smooth muscle.Semantic proximity Read

Cardiac remodeling pathways do not accelerate disease onset and severity in a mouse model of PLN-R14del cardiomyopathySemantic proximity Read

Intermittent pressure overload triggers hypertrophy-independent cardiac dysfunction and vascular rarefaction.Semantic proximity Read

Thymosin β4 preserves vascular smooth muscle phenotype in atherosclerosis via regulation of Low Density Lipoprotein Related Protein 1 (LRP1)Semantic proximity Read

Cardiomyocyte BRAF is a key signalling intermediate in cardiac hypertrophy in miceSemantic proximity Read

Impaired systolic function in Loeys-Dietz syndrome: a novel cardiomyopathy?Semantic proximity Read

<i>MYH11</i> rare variant augments aortic growth and induces cardiac hypertrophy and heart failure with pressure overloadSemantic proximity Read

Old mice have a functionally distinct contractile reserve from obese miceSemantic proximity Read

Magel2 deficiency promotes cardiac remodeling and increases arrhythmogenic susceptibility in a mouse model relevant to Prader-Willi and Schaaf-Yang syndromes.Semantic proximity Read

Involvement of GPR37L1 in murine blood pressure regulation and human cardiac disease pathophysiology.Semantic proximity Read

Angiotensin II–Driven Coronary Vasculopathy and Pressure-Overload Myocardial Remodeling Represent Distinct Vascular PhenotypesSemantic proximity Read

Long Non-Coding RNA Malat-1 Is Dispensable during Pressure Overload-Induced Cardiac Remodeling and Failure in MiceSemantic proximity Read