Article
Intracellular sodium sensing: SIK1 network, hormone action and high blood pressure.
Biochimica et biophysica acta - 1 Dec 2010
Jaitovich Ariel, Bertorello Alejandro M
Abstract excerpt
Sodium is the main determinant of body fluid distribution. Sodium accumulation causes water retention and, often, high blood pressure. At the cellular level, the concentration and active transport of sodium is handled by the enzyme Na(+),K(+)-ATPase, whose appearance enabled evolving primitive cells to cope with osmotic stress and contributed to the complexity of mammalian organisms. Na(+),K(+)-ATPase is a...
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