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Article

The suppression of ghrelin signaling mitigates age‐associated thermogenic impairment.

Aging - 1 Dec 2014

Lin Ligen, Lee Jong Han, Bongmba Odelia Y N, Ma Xiaojun, Zhu Xiongwei, Sheikh-Hamad David, Sun Yuxiang

Abstract excerpt

Aging is associated with severe thermogenic impairment, which contributes to obesity and diabetes in aging. We previously reported that ablation of the ghrelin receptor, growth hormone secretagogue receptor (GHS‐R), attenuates age‐associated obesity and insulin resistance. Ghrelin and obestatin are derived from the same preproghrelin gene. Here we showed that in brown adipocytes, ghrelin decreases the expression...

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Identifiers

PMID: 25543537
DOI: 10.18632/aging.100706
PMCID: PMC4298363

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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