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Article

Mice lacking ghrelin receptors resist the development of diet-induced obesity.

The Journal of clinical investigation - 1 Dec 2005

Zigman Jeffrey M, Nakano Yoshihide, Coppari Roberto, Balthasar Nina, Marcus Jacob N, Lee Charlotte E, Jones Juli E, Deysher Amy E, Waxman Amanda R, White Ryan D, Williams Todd D, Lachey Jennifer L, Seeley Randy J, Lowell Bradford B, Elmquist Joel K

Abstract excerpt

Ghrelin is the endogenous ligand for the growth hormone secretagogue receptor (GHSR; ghrelin receptor). Since its discovery, accumulating evidence has suggested that ghrelin may play a role in signaling and reversing states of energy insufficiency. For example, ghrelin levels rise following food deprivation, and ghrelin administration stimulates feeding and increases body weight and adiposity. However, recent...

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Source

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Identifiers

PMID: 16322794
DOI: 10.1172/JCI26002
PMCID: PMC1297251

Genes

GHSR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Mice lacking ghrelin receptors resist the development of diet-induced obesity.PMID 16322794Read ↗

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Ablations of ghrelin and ghrelin receptor exhibit differential metabolic phenotypes and thermogenic capacity during aging.Semantic proximity Read ↗

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Genetic deletion of the ghrelin receptor (GHSR) impairs growth and blunts endocrine response to fasting in Ghsr-IRES-Cre mice.Semantic proximity Read ↗

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The GOAT-ghrelin system is not essential for hypoglycemia prevention during prolonged calorie restriction.Semantic proximity Read ↗

Thermogenic characterization of ghrelin receptor null mice.Semantic proximity Read ↗

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The effects of vertical sleeve gastrectomy in rodents are ghrelin independent.Semantic proximity Read ↗

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