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Article

Enhanced responsiveness of Ghsr Q343X rats to ghrelin results in enhanced adiposity without increased appetite.

Science signaling - 19 Apr 2016

Chebani Yacine, Marion Candice, Zizzari Philippe, Chettab Khadidja, Pastor Marie, Korostelev Marie, Geny David, Epelbaum Jacques, Tolle Virginie, Morisset-Lopez Séverine, Pantel Jacques

Abstract excerpt

The ability of the gut hormone ghrelin to promote positive energy balance is mediated by the growth hormone secretagogue receptor (GHSR). GHSR is a G protein-coupled receptor (GPCR) that is found centrally and peripherally and that can signal in a ligand-independent manner basally or when heterodimerized with other GPCRs. However, current Ghsr knockout models cannot dissect ghrelin-dependent and...

Read the complete abstract on PubMed

Topics

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Share to Adiposity
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Caloric Restriction

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Share to Growth Hormone

Share to Receptors, Ghrelin

Source

Identifiers

PMID: 27095593
DOI: 10.1126/scisignal.aae0374

Genes

GHSR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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