Article
Growth hormone action predicts age-related white adipose tissue dysfunction and senescent cell burden in mice.
Aging - 1 Jul 2014
Stout Michael B, Tchkonia Tamara, Pirtskhalava Tamar, Palmer Allyson K, List Edward O, Berryman Darlene E, Lubbers Ellen R, Escande Carlos, Spong Adam, Masternak Michal M, Oberg Ann L, LeBrasseur Nathan K, Miller Richard A, Kopchick John J, Bartke Andrzej, Kirkland James L
Abstract excerpt
The aging process is associated with the development of several chronic diseases. White adipose tissue (WAT) may play a central role in age-related disease onset and progression due to declines in adipogenesis with advancing age. Recent reports indicate that the accumulation of senescent progenitor cells may be involved in age-related WAT dysfunction. Growth hormone (GH) action has profound effects on adiposity...
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