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Article

Ghrelin receptor (GHS-R1A) agonists show potential as interventive agents during aging.

Annals of the New York Academy of Sciences - 1 Nov 2007

Smith Roy G, Sun Yuxiang, Jiang Hong, Albarran-Zeckler Rosie, Timchenko Nikolai

Abstract excerpt

Administration of an orally active agonist (MK-0677) of the growth hormone secretagogue receptor (GHS-R1a) to elderly subjects restored the amplitude of endogenous episodic growth hormone (GH) release to that of young adults. Functional benefits include increased lean mass and bone density and modest improvements in strength. In old mice, a similar agonist partially restored function to the thymus and reduced...

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PMID: 18056963
DOI: 10.1196/annals.1404.023

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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