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Article

Impaired myogenic response and autoregulation of cerebral blood flow is rescued in CYP4A1 transgenic Dahl salt-sensitive rat.

American journal of physiology. Regulatory, integrative and comparative physiology - 1 Mar 2015

Fan Fan, Geurts Aron M, Murphy Sydney R, Pabbidi Mallikarjuna R, Jacob Howard J, Roman Richard J

Abstract excerpt

We have reported that a reduction in renal production of 20-HETE contributes to development of hypertension in Dahl salt-sensitive (SS) rats. The present study examined whether 20-HETE production is also reduced in the cerebral vasculature of SS rats and whether this impairs the myogenic response and autoregulation of cerebral blood flow (CBF). The production of 20-HETE, the myogenic response of middle cerebral...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cerebrovascular Circulation

Share to Rats, Inbred Dahl

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Share to Sodium Chloride, Dietary

Share to Vascular Remodeling

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Source

Open in PubMed Open full text

Identifiers

PMID: 25540098
DOI: 10.1152/ajpregu.00256.2014
PMCID: PMC4346760

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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