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Article

Transfer of the CYP4A region of chromosome 5 from Lewis to Dahl S rats attenuates renal injury

9 Oct 2008

Abstract excerpt

This study examined the effect of transfer of overlapping regions of chromosome 5 that includes (4A(+)) or excludes (4A(-)) the cytochrome P-450 4A (CYP4A) genes from the Lewis rat on the renal production of 20-hydroxyeicosatetraenoic acid (20-HETE) and the development of hypertension-induced renal disease in congenic strains of Dahl salt-sensitive (Dahl S) rats. The production of 20-HETE was higher in the outer...

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PMID: 18842817
DOI: 10.1152/ajprenal.90525.2008

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