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Article

Androgen-sensitive hypertension associated with soluble guanylate cyclase-α<sub>1</sub> deficiency is mediated by 20-HETE

4 May 2016

Abstract excerpt

Dysregulated nitric oxide (NO) signaling contributes to the pathogenesis of hypertension, a prevalent and often sex-specific risk factor for cardiovascular disease. We previously reported that mice deficient in the α1-subunit of the NO receptor soluble guanylate cyclase (sGCα1 (-/-) mice) display sex- and strain-specific hypertension: male but not female sGCα1 (-/-) mice are hypertensive on an 129S6 (S6) but not...

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PMID: 27199131
DOI: 10.1152/ajpheart.00877.2015

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