Article
Failure to vasodilate in response to salt loading blunts renal blood flow and causes salt-sensitive hypertension.
Cardiovascular research - 1 Jan 2021
Wu Jing, Agbor Larry N, Fang Shi, Mukohda Masashi, Nair Anand R, Nakagawa Pablo, Sharma Avika, Morgan Donald A, Grobe Justin L, Rahmouni Kamal, Weiss Robert M, McCormick James A, Sigmund Curt D
Abstract excerpt
AIMS: Salt-sensitive (SS) hypertension is accompanied by impaired vasodilation in the systemic and renal circulation. However, the causal relationship between vascular dysfunction and salt-induced hypertension remains controversial. We sought to determine whether primary vascular dysfunction, characterized by a failure to vasodilate during salt loading, plays a causal role in the pathogenesis of SS hypertension....
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