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Article

Aberrant RNA homeostasis in amyotrophic lateral sclerosis: potential for new therapeutic targets?

Neurodegenerative disease management - 1 Jan 2014

Donnelly Christopher J, Grima Jonathan C, Sattler Rita

Abstract excerpt

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder characterized by progressive motor neuron degeneration. The disease pathogenesis is multifaceted in that multiple cellular and molecular pathways have been identified as contributors to the disease progression. Consequently, numerous therapeutic targets have been pursued for clinical development, unfortunately with little success. The...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 25531686
DOI: 10.2217/nmt.14.36
PMCID: PMC4308292

Genes

FUS
TARDBP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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