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Article

Implications of miRNAs dysregulation in amyotrophic lateral sclerosis: Challenging for clinical applications

21 Feb 2023

Abstract excerpt

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by the selective degeneration of upper and lower motor neurons. Currently, there are no effective biomarkers and fundamental therapies for this disease. Dysregulation in RNA metabolism plays a critical role in the pathogenesis of ALS. With the contribution of Next Generation Sequencing, the functions of non-coding RNAs (ncRNAs)...

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PMID: 36895420
DOI: 10.3389/fnins.2023.1131758

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