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Failure to Deliver and Translate—New Insights into RNA Dysregulation in ALS

17 Aug 2017

Abstract excerpt

Amyotrophic Lateral Sclerosis (ALS) is a progressive and fatal neurodegenerative disease affecting both upper and lower motor neurons. The molecular mechanisms underlying disease pathogenesis remain largely unknown. Multiple genetic loci including genes involved in proteostasis and ribostasis have been linked to ALS providing key insights into the molecular mechanisms underlying disease. In particular, the...

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PMID: 28860970
DOI: 10.3389/fncel.2017.00243

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