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Stress Granule Dysregulation in Amyotrophic Lateral Sclerosis

17 Nov 2020

Abstract excerpt

Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease with no current cure. ALS causes degeneration of both upper and lower motor neurons leading to atrophy of the innervating muscles and progressive paralysis. The exact mechanism of the pathology of ALS is unknown. However, 147 genes have been identified that are causative, associated with, or modify disease progression. While the...

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PMID: 33281563
DOI: 10.3389/fncel.2020.598517

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