Connecting RNA-Modifying Similarities of TDP-43, FUS, and SOD1 with MicroRNA Dysregulation Amidst A Renewed Network Perspective of Amyotrophic Lateral Sclerosis Proteinopathy.

Abstract excerpt

Beyond traditional approaches in understanding amyotrophic lateral sclerosis (ALS), multiple recent studies in RNA-binding proteins (RBPs)-including transactive response DNA-binding protein (TDP-43) and fused in sarcoma (FUS)-have instigated an interest in their function and prion-like properties. Given their prominence as hallmarks of a highly heterogeneous disease, this prompts a re-examination of the specific...

Topics

• Amyotrophic Lateral Sclerosis
• DNA-Binding Proteins
• Humans
• MicroRNAs
• Mutation
• RNA Splicing
• RNA-Binding Protein FUS
• RNA-Binding Proteins
• Superoxide Dismutase-1