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TDP-43 and FUS/TLS: emerging roles in RNA processing and neurodegeneration

15 Apr 2010

Abstract excerpt

Amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD) are neurodegenerative diseases with clinical and pathological overlap. Landmark discoveries of mutations in the transactive response DNA-binding protein (TDP-43) and fused in sarcoma/translocated in liposarcoma (FUS/TLS) as causative of ALS and FTLD, combined with the abnormal aggregation of these proteins, have initiated a shifting...

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PMID: 20400460
DOI: 10.1093/hmg/ddq137

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