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Article

Dysregulation of RNA-Binding Proteins in Amyotrophic Lateral Sclerosis

29 May 2020

Abstract excerpt

, and disease onset/progression. RBPs are a group of evolutionally conserved proteins that participate in multiple steps of RNA metabolism, including splicing, polyadenylation, mRNA stability, localization, and translation. Dysregulation of RBPs, as a consequence of gene mutations, impaired nucleocytoplasmic trafficking, posttranslational modification (PTM), aggregation, and sequestration by abnormal RNA foci,...

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PMID: 32547363
DOI: 10.3389/fnmol.2020.00078

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