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Article

RNA metabolism in ALS: When normal processes become pathological

20 Feb 2014

Abstract excerpt

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease caused by the death of motor neurons. While the exact molecular and cellular basis for motor neuron death is not yet fully understood, the current conceptualization is that multiple aberrant biological processes contribute. Among these, one of the most compelling is based on alterations of RNA metabolism. In this review, we examine how the...

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PMID: 24555412
DOI: 10.3109/21678421.2014.881377

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