Article
RNA quality control and protein aggregates in amyotrophic lateral sclerosis: a review.
Muscle & nerve - 1 Mar 2013
Verma Ashok, Tandan Rup
Abstract excerpt
Amyotrophic lateral sclerosis (ALS) is the most common motor neuron disease in adults. The biologic basis of ALS remains unknown. However, ALS research has taken a dramatic turn over the past 4 years. Ground breaking discoveries of mutations of genes that encode RNA processing proteins, and demonstration that abnormal aggregates of these and other proteins precede motor neuron loss in familial and sporadic ALS,...
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