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Article

Mechanisms of FUS mutations in familial amyotrophic lateral sclerosis.

Brain research - 15 Sept 2016

Shang Yulei, Huang Eric J

Abstract excerpt

Recent advances in the genetics of amyotrophic lateral sclerosis (ALS) have provided key mechanistic insights to the pathogenesis of this devastating neurodegenerative disease. Among many etiologies for ALS, the identification of mutations and proteinopathies in two RNA binding proteins, TDP-43 (TARDBP or TAR DNA binding protein 43) and its closely related RNA/DNA binding protein FUS (fused in sarcoma), raises...

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Identifiers

PMID: 27033831
DOI: 10.1016/j.brainres.2016.03.036
PMCID: PMC5003642

Genes

FUS
TARDBP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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