RNA Dysregulation in Amyotrophic Lateral Sclerosis

Abstract excerpt

Amyotrophic lateral sclerosis (ALS) is the most common adult-onset motor neuron disease and is characterized by the degeneration of upper and lower motor neurons. It has become increasingly clear that RNA dysregulation is a key contributor to ALS pathogenesis. The major ALS genes SOD1, TARDBP, FUS and C9orf72 are involved in aspects of RNA metabolism processes such as mRNA transcription, alternative splicing, RNA...