Antibody light-chain-restricted recognition of the site of immune pressure in the RV144 HIV-1 vaccine trial is phylogenetically conserved.

doi:10.1016/j.immuni.2014.11.014

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Article

Antibody light-chain-restricted recognition of the site of immune pressure in the RV144 HIV-1 vaccine trial is phylogenetically conserved.

Immunity - 18 Dec 2014

Wiehe Kevin, Easterhoff David, Luo Kan, Nicely Nathan I, Bradley Todd, Jaeger Frederick H, Dennison S Moses, Zhang Ruijun, Lloyd Krissey E, Stolarchuk Christina, Parks Robert, Sutherland Laura L, Scearce Richard M, Morris Lynn, Kaewkungwal Jaranit, Nitayaphan Sorachai, Pitisuttithum Punnee, Rerks-Ngarm Supachai, Sinangil Faruk, Phogat Sanjay, Michael Nelson L, Kim Jerome H, Kelsoe Garnett, Montefiori David C, Tomaras Georgia D, Bonsignori Mattia, Santra Sampa, Kepler Thomas B, Alam S Munir, Moody M Anthony, Liao Hua-Xin, Haynes Barton F

Abstract excerpt

In HIV-1, the ability to mount antibody responses to conserved, neutralizing epitopes is critical for protection. Here we have studied the light chain usage of human and rhesus macaque antibodies targeted to a dominant region of the HIV-1 envelope second variable (V2) region involving lysine (K) 169, the site of immune pressure in the RV144 vaccine efficacy trial. We found that humans and rhesus macaques used...

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Identifiers

PMID: 25526306
DOI: 10.1016/j.immuni.2014.11.014
PMCID: PMC4324565

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