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Article

Cooperation between somatic mutation and germline-encoded residues enables antibody recognition of HIV-1 envelope glycans.

PLoS pathogens - 1 Dec 2019

Wu Nelson R, Nicely Nathan I, Lee Esther M, Reed Rachel K, Watts Brian E, Cai Fangping, Walkowicz William E, Aussedat Baptiste, Jones Julia A, Eaton Amanda, Trama Ashley M, Alam S Munir, Montefiori David C, Haynes Barton F, Saunders Kevin O

Abstract excerpt

Viral glycoproteins are a primary target for host antibody responses. However, glycans on viral glycoproteins can hinder antibody recognition since they are self glycans derived from the host biosynthesis pathway. During natural HIV-1 infection, neutralizing antibodies are made against glycans on HIV-1 envelope glycoprotein (Env). However, such antibodies are rarely elicited with vaccination. Previously, the...

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Share to AIDS Vaccines
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to env Gene Products, Human Immunodeficiency Virus

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Identifiers

PMID: 31841553
DOI: 10.1371/journal.ppat.1008165
PMCID: PMC6936856

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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