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Article

V2-Directed Vaccine-like Antibodies from HIV-1 Infection Identify an Additional K169-Binding Light Chain Motif with Broad ADCC Activity

1 Dec 2018

Abstract excerpt

Antibodies that bind residue K169 in the V2 region of the HIV-1 envelope correlated with reduced risk of infection in the RV144 vaccine trial but were restricted to two ED-motif-encoding light chain genes. Here, we identify an HIV-infected donor with high-titer V2 peptide-binding antibodies and isolate two antibody lineages (CAP228-16H/19F and CAP228-3D) that mediate potent antibody-dependent cell-mediated...

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Identifiers

PMID: 30540944
DOI: 10.1016/j.celrep.2018.11.058

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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