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Article

Structural analysis of the unmutated ancestor of the HIV-1 envelope V2 region antibody CH58 isolated from an RV144 vaccine efficacy trial vaccinee.

EBioMedicine - 1 Jul 2015

Nicely Nathan I, Wiehe Kevin, Kepler Thomas B, Jaeger Frederick H, Dennison S Moses, Rerks-Ngarm Supachai, Nitayaphan Sorachai, Pitisuttithum Punnee, Kaewkungwal Jaranit, Robb Merlin L, O'Connell Robert J, Michael Nelson L, Kim Jerome H, Liao Hua-Xin, Munir Alam S, Hwang Kwan-Ki, Bonsignori Mattia, Haynes Barton F

Abstract excerpt

Human monoclonal antibody CH58 isolated from an RV144 vaccinee binds at Lys169 of the HIV-1 Env gp120 V2 region, a site of vaccine-induced immune pressure. CH58 neutralizes HIV-1 CRF_01 AE strain 92TH023 and mediates ADCC against CD4 + T cell targets infected with CRF_01 AE tier 2 virus. CH58 and other antibodies that bind to a gp120 V2 epitope have a second light chain complementarity determining region (LCDR2)...

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Identifiers

PMID: 26288844
DOI: 10.1016/j.ebiom.2015.06.016
PMCID: PMC4534707

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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