Article

Improved HIV-1 drug resistance mutation prediction using quasispecies reconstruction supported analysis

2021-05-25

Abstract excerpt

Accurate and sensitive approaches to detect HIV-1 drug resistance mutations (DRMs) are indispensable for the paradigm of ‘treatment as prevention’. While HIV-1 proviral DNA allows sensitive high throughput sequencing (HTS)-based DRM detection, its applicability is limited by presence of defective genomes. This study demonstrates application of quasispecies reconstruction algorithms (QRAs) to improve DRM detection...

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Literature Corpus work: 85b9565d-01a3-5b78-b9a1-010ff79b4ad1
DOI: 10.1101/2021.05.24.445423

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