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Article

Mutational and fitness landscapes of an RNA virus revealed through population sequencing.

Nature - 30 Jan 2014

Acevedo Ashley, Brodsky Leonid, Andino Raul

Abstract excerpt

RNA viruses exist as genetically diverse populations. It is thought that diversity and genetic structure of viral populations determine the rapid adaptation observed in RNA viruses and hence their pathogenesis. However, our understanding of the mechanisms underlying virus evolution has been limited by the inability to accurately describe the genetic structure of virus populations. Next-generation sequencing...

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PMID: 24284629
DOI: 10.1038/nature12861
PMCID: PMC4111796

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