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Article

The Determination of HIV-1 RT Mutation Rate, Its Possible Allosteric Effects, and Its Implications on Drug Resistance.

Viruses - 9 Mar 2020

Yeo Joshua Yi, Goh Ghin-Ray, Su Chinh Tran-To, Gan Samuel Ken-En

Abstract excerpt

The high mutation rate of the human immunodeficiency virus type 1 (HIV-1) plays a major role in treatment resistance, from the development of vaccines to therapeutic drugs. In addressing the crux of the issue, various attempts to estimate the mutation rate of HIV-1 resulted in a large range of 10-5-10-3 errors/bp/cycle due to the use of different types of investigation methods. In this review, we discuss the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 32182845
DOI: 10.3390/v12030297
PMCID: PMC7150816

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